Methylome Analysis in Chickens Immunized with Infectious Laryngotracheitis Vaccine
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Methylome Analysis in Chickens Immunized with Infectious Laryngotracheitis Vaccine
In this study we investigated the methylome of chickens immunized with Infectious laryngotracheitis (ILT) vaccine derived from chicken embryos. Methyl-CpG binding domain protein-enriched genome sequencing (MBD-Seq) method was employed in the detection of the 1,155 differentially methylated regions (DMRs) across the entire genome. After validation, we ascertained the genomic DMRs distribution an...
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1. The characteristic lesions of infectious laryngotracheitis are ordinarily restricted to the respiratory tract and are most pronounced in the larynx and trachea. Sometimes the eyelids are affected. A certain percentage of the cases are associated with bronchitis and peribronchitis, pneumonic areas and hemorrhages in the lung, while the involvement of the nasal passages, communicating sinuses,...
متن کاملLaryngotracheitis Virus in Chickens
Infectious laryngotracheitis can be produced in chickens as an experimental model of severe nonfatal rhinitis and sinusitis. Inoculated intranasally into unanesthetized baby chicks it remains limited to the nasal fossa, produces acute desquamation of all nasal epithelia, results in functional recovery of the respiratory epithelium, but leaves important residual abnormalities. From the earliest ...
متن کاملAvian infectious laryngotracheitis.
Avian infectious laryngotracheitis (ILT) herpesvirus continues to cause sporadic cases of respiratory disease in chickens world-wide. Sources of transmission of ILT infection are three-fold, namely: chickens with acute upper respiratory tract disease, latently infected 'carrier' fowls which excrete infectious laryngotracheitis virus (ILTV) when stressed, and all fomites (inanimate articles as w...
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The role of mucosal antibody in recovery from a primary infection and resistance to reinfection with infectious laryngotracheitis (ILT) herpesvirus was studied in bursectomized chickens, which were unable to synthesize specific antibodies. Viral antigen in the infected trachea was assessed by indirect immunofluorescence on tissue sections and by ELISA. The ability of bursectomized chickens to r...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0100476